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A Perfect Storm in the Operating Room Case Study Write-Up February 2, 2018

A Perfect Storm in the Operating Room Write-Up

By: Mariah Lopez 


Muscle Contraction occurs when calcium causes the troponin to change its shape which consequently changes the function of the Troponin. When the Troponin changes its shape it moves the Tropomyosin which exposing the myosin binding site. Then the myosin binds the actin and that's when the muscle contracts. Malignant Hyperthermia also known as MH is when the body has a severe reaction to certain types of medications used in general anesthesia. Malignant Hyperthermia causes the body to dangerously rise in body temperature, causes muscle spasms and a fast heart rate, patchy skin and low blood pressure. MH is inherited through genetic defects. Ice packs, cooling blankets and fans may be used to help reduce body temperature. Malignant Hyperthermia is triggered by the drugs used in the general anesthesia, such as halothane, sevoflurane, and desflurane. The "metabolic storm" that develops during MH is refers the the symptoms of MH such as rapid heart rate and breathing and rise in temperature because one malfunction causes the whole body to shut down. The body temperature rises during MH due to the muscle not being able to relax so they kept generating heat, which causes the temperature the constantly rises. Cardiac and Smooth Muscle are not impacted because they aren't triggered by the same process of skeletal muscle because of the process of calcium release.  

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